منابع مشابه
Immunogenomic approaches to study host immunity to enteric pathogens.
With increasing consumer demands for safe poultry products, effective control of disease-causing pathogens is becoming a major challenge to the poultry industry. Many chicken pathogens enter the host through the gastrointestinal tract, and over the past few decades, in-feed antibiotics and active vaccination have been the 2 main mechanisms of disease control. However, increasing public concerns...
متن کاملEnteric Virome Sensing-Its Role in Intestinal Homeostasis and Immunity.
Pattern recognition receptors (PRRs) sensing commensal microorganisms in the intestine induce tightly controlled tonic signaling in the intestinal mucosa, which is required to maintain intestinal barrier integrity and immune homeostasis. At the same time, PRR signaling pathways rapidly trigger the innate immune defense against invasive pathogens in the intestine. Intestinal epithelial cells and...
متن کاملSerpinB2 is critical to Th2 immunity against enteric nematode infection.
SerpinB2, a member of the serine protease inhibitor family, is expressed by macrophages and is significantly upregulated by inflammation. Recent studies implicated a role for SerpinB2 in the control of Th1 and Th2 immune responses, but the mechanisms of these effects are unknown. In this study, we used mice deficient in SerpinB2 (SerpinB2(-/-)) to investigate its role in the host response to th...
متن کاملModeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs
BACKGROUND Rotavirus vaccines have poor efficacy in infants from low- and middle-income countries. Gut microbiota is thought to influence the immune response to oral vaccines. Thus, we developed a gnotobiotic (Gn) pig model of enteric dysbiosis to study the effects of human gut microbiota (HGM) on immune responses to rotavirus vaccination, and the effects of rotavirus challenge on the HGM by co...
متن کاملComplex Adaptive Immunity to Enteric Fevers in Humans: Lessons Learned and the Path Forward
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S. Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats throughout the world. Although two licensed typhoid vaccines are currently available, they are only moderately protective and immunogenic necessitating the development of novel vaccines. A major obstacle in the devel...
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ژورنال
عنوان ژورنال: Veterinary Clinics of North America: Food Animal Practice
سال: 2018
ISSN: 0749-0720
DOI: 10.1016/j.cvfa.2017.10.006